Depression
Conditions
Interventions
Control group:none
Treatment group:Repetitive transcranial magnetic stimulation therapy
Sponsors
The First Affiliated Hospital of Air Force Military Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion Criteria for Patients: (1). Female aged 18–40 years; (2). Right-handed; (3). Meet the diagnostic criteria for depressive disorder according to the *Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5)*, and have received no pharmacological treatment or have been withdrawn from such treatment for at least 4 weeks; (4). Have a total score of >=17 and <24 on the 17-item Hamilton Depression Rating Scale (HDRS); (5). After fully understanding the safety of repetitive transcranial magnetic stimulation (rTMS) and PET-CT/MRI, voluntarily agree to cooperate and sign the informed consent form. 2. Inclusion Criteria for Healthy Subjects: (1). Female aged 18–40 years; (2). Right-handed; (3). In good general health with no organic or mental disorders; (4). After fully understanding the safety of PET-CT/MRI, voluntarily agree to cooperate and sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Presence of metal implants, renal insufficiency, diabetes mellitus, or any other contraindication to PET-CT/MRI scanning or transcranial magnetic stimulation (TMS) therapy; 2. Use of medications that affect glucose metabolism (e.g., glucocorticoids, beta-blockers, thiazide diuretics, fluoroquinolones, thyroid hormone preparations) within the past three months, or presence of other diseases that may affect cerebral glucose metabolism; 3. Depression secondary to bipolar disorder or other psychiatric disorders; 4. Prior diagnosis of any other mental disorder, or use of psychoactive substances (e.g., sedatives, hypnotics) within the past three months; 5. Receipt of any form of antidepressant treatment (including medication, physical therapy, or psychotherapy) within one month prior to enrollment; 6. Presence of psychotic symptoms requiring concomitant antipsychotic medication; 7. High risk of suicide, or occurrence of suicidal or severe self-injurious behavior requiring urgent intervention; 8. Being in the menstrual period, currently pregnant, or planning to become pregnant during the trial period; 9. Any other condition that, in the investigator's judgment, makes the subject unsuitable for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standard Uptake Value;Hamilton Depression Rating Scale score;Montgomery-Asberg Depression Rating Scale score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-Rating Depression Scale score; | — |
Countries
China
Contacts
Public ContactWang Huaning
The First Affiliated Hospital of Air Force Military Medical University
Outcome results
None listed