Ischemic stroke
Conditions
Interventions
Neuroregulation group:Multimodal neuroregulation (transcranial focused ultrasound stimulation) targeting specific neural regions. Specific parameters: using NeuroFUSDPX-500 device, 4-element transduce
Control group:Sham stimulation or routine treatment. Specific procedure: receiving sham stimulation during the regulation phase, all procedures (navigation localization, gel application, etc.) identic
Sponsors
Taizhou People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients diagnosed with first-onset ischemic stroke confirmed by neuroimaging; 2. Unilateral limb motor impairment; 3. Modified Ashworth Scale (MAS) score for the upper limb <= 3, Brunnstrom stage between II and V, and upper limb Fugl-Meyer Assessment (FMA-UE) score between 15 and 60 (inclusive); 4. Age between 18 and 75 years, time since onset between 21 days and 6 months, in the subacute or recovery phase; 5. Stable vital signs, no impaired consciousness, informed consent to participate in the study, ability to cooperate with diagnosis and treatment, and approval from the hospital ethics committee.
Exclusion criteria
Exclusion criteria: 1. Contraindications to MRI; 2. Infarction involving the thalamus; 3. Risk of intracranial hemorrhage; 4. Presence of intracranial metal implants, cardiac pacemaker, or cochlear implants; 5. Unstable condition, severe cognitive impairment, or mental disorders that prevent understanding of the study content or cooperation with assessments; 6. Presence of fractures, joint contractures, severe limb spasticity, or other conditions affecting limb motor function; 7. Use of medications that alter cortical excitability.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Upper Limb Fugl-Meyer Assessment Score;Brunnstrom Staging;Ashworth Scale;Imaging Data (Analysis of ALFF, fALFF, ReHo, FC, FA from Functional MRI and Diffusion Tensor Imaging);EEG and Near-Infrared Spectroscopy Measurement of Resting-State and Task-State EEG Spectral Power, HbO, and Functional Connectivity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood Biochemistry, Complete Blood Count, CRP, IL-6, S100ß, BDNF; | — |
Countries
China
Contacts
Public ContactZhao Gaonian
Taizhou People's Hospital
Outcome results
None listed