Perioperative Neurocognitive Disorders
Conditions
Interventions
Case series :None
Sponsors
Tianjin Third Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Voluntarily sign informed consent; 2. Elderly patients undergoing elective abdominal surgery under general anesthesia; 3. Age >=65 years old; 4. ASA grade II to III; 5. Body mass index (BMI) 18.5-30 kg/m^2
Exclusion criteria
Exclusion criteria: 1. Patients with previous history of psychosis, brain trauma, dementia, cerebrovascular disease, or other diseases and cognitive impairment; 2. Long-term use of sedatives, hypnotics and anti-psychotic drugs; 3. Patients with severe liver and kidney dysfunction, cardiopulmonary dysfunction, and suspected severe neurocognitive impairment (MMSE score <24); 4. Patients who are unable to complete the hearing test (extremely severe hearing loss or wearing hearing AIDS, unable to cooperate with the test for special reasons); 5. History of allergy to narcotic drugs; Other patients who, in the judgment of their physicians, were not considered to be suitable participants in the study; 6. Alcoholism or drug dependence; 7. Patients with serious diseases of the heart, liver, kidney, respiratory, nervous system and other systems; 8. Severe pain medications fail to relieve patients; 9. Patients deemed by the clinician to be ineligible for participation in the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of perioperative neurocognitive dysfunction; | — |
Secondary
| Measure | Time frame |
|---|---|
| Content of phosphorylated Tau 181 and 217;Amyloid ß-40 and ß-42 content; | — |
Countries
China
Contacts
Public ContactHaiyun Wang
Tianjin Third Central Hospital
Outcome results
None listed