None
Conditions
Interventions
Remimazolam Tosylate Group:General anesthesia with remimazolam tosylate
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, regardless of gender 2. Normal BMI (18.5-23.9 kg/m²) but meeting one of the hidden obesity diagnostic criteria: Body fat percentage: male >=20%, female >=30% Waist-to-hip ratio: male >0.9, female >0.85 Visceral fat area: male >=100 cm², female >=80 cm² 3. Elective unilateral biportal endoscopic (UBE) surgery with anesthesia duration <=2 hours 4. ASA physical status class ?-? 5. Signed informed consent
Exclusion criteria
Exclusion criteria: 1. Allergy to propofol emulsifier (soybean lecithin) or remimazolam 2. History of epilepsy or convulsions 3. Pregnant or breastfeeding women 4. Uncontrolled hypertension (systolic BP>160 mmHg or diastolic BP>100 mmHg) 5. Severe cardiopulmonary diseases (e.g., myocardial infarction, heart failure, acute asthma exacerbation) 6. Severe hepatic or renal insufficiency (Child-Pugh class C, Cr>2 mg/dL) 7. Coagulation disorders (INR>1.5, platelet count2 hours 11. Recent use of CYP3A4 inhibitors (e.g., ketoconazole) or diuretics 12. Preoperative acute infection or inflammation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Extubation time (spontaneous breathing recovery with SpO2 >= 95%); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthesia maintenance stability;Postoperative 24-hour pain VAS score;Postoperative 24-hour patient satisfaction;Incidence of postoperative nausea and vomiting (PONV);Incidence of hypoxemia; | — |
Countries
China
Contacts
Public ContactYan Wei
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed