Intrahepatic Cholestasis of Pregnancy (ICP)
Conditions
Interventions
Sponsors
Women and Children's Hospital of Ningbo University
Eligibility
Sex/Gender
Female
Age
25 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Gestational age >= 28 weeks, with regular prenatal care at our hospital. 2. Mild intrahepatic cholestasis of pregnancy (ICP): serum total bile acid level >10 mmol/L and =40 mmol/L. 3. Age range: 25-40 years.
Exclusion criteria
Exclusion criteria: 1. Incomplete clinical data; 2. Fetal congenital malformations; 3. Multiple gestation; 4. Various acute or chronic liver diseases (including Wilson's disease, cholecystitis, primary sclerosing cholangitis, primary biliary cholangitis, alpha-1 antitrypsin deficiency, symptomatic cholelithiasis, cytomegalovirus infection, Epstein–Barr virus infection, autoimmune hepatitis, and acute fatty liver of pregnancy); 5. Concurrent pregnancy-related comorbidities that may elevate inflammatory markers, such as gestational hypertension, gestational diabetes mellitus, and inflammatory conditions occurring during pregnancy (e.g., bacterial infections).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maternal intrahepatic cholestasis of pregnancy (ICP) levels and disease severity (mild, severe);Neonatal outcomes after delivery;Serum alanine aminotransferase (ALT);Serum aspartate aminotransferase (AST);Serum triglycerides (TG);Serum total cholesterol;Low-density lipoprotein (LDL);High-density lipoprotein (HDL);Placental inflammatory cytokine interleukin-1 beta (IL-1ß);Placental inflammatory cytokine interleukin-18 (IL-18);Placental NLRP3;Placental caspase-1;NLRP3 mRNA;Caspase-1 mRNA;NLRP3 protein;Caspase-1 protein;Disease severity; | — |
Countries
China
Contacts
Public ContactHe Xiaobo
Women and Children's Hospital of Ningbo University
Outcome results
None listed