Endometrial atypical hyperplasia, endometrial cancer, repeated implantation failures
Conditions
Interventions
Control group:N/A
Repeated implantation failures group:N/A
Atypical hyperplasia of endometrium/endometrial carcinoma group:N/A
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 38 Years
Inclusion criteria
Inclusion criteria: 1. Age range of 20-38 years old, normal BMI range; 2. Normal ovarian reserve, amh>1.5; 3. First or second resuscitation transplant; 4.On the day of transplantation, the thickness of the endometrium should be greater than 8mm.
Exclusion criteria
Exclusion criteria: 1. No endometrial lesions; 2. No adenomyosis or endometriosis; 3. No intrauterine adhesions; 4. No recurrence of implant failure or recurrent miscarriage; 5. No medical disease (diabetes, insulin resistance, thyroid abnormality, hypertension, immune disease).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RNA seq detection and analysis of differential gene expression of FGF1/PIM1/TLR4 in samples from different groups;Identification of Specific Cell Groups and Gene Expression Differences by Single Cell RNA Sequencing;Multi factor detection of Th1/2, VEGF/IL-6 and other immune factors in different groups using liquid phase protein chip;Proteomic and metabolomic mass spectrometry detection of differential expression of proteins, lipids, amino acid metabolites, etc; | — |
Countries
China
Contacts
Public ContactTao Tao
Peking Union Medical College Hospital
Outcome results
None listed