schizophrenia
Conditions
Interventions
Exposure group(Suffering from schizophrenia):None
Non-exposure group(healthy person):None
Sponsors
Peking University Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1.Patient Group: (1)Meets the DSM-5 diagnostic criteria for schizophrenia; (2)Aged 18 to 45 years; Han ethnicity; right-handed; (3)Not currently taking any medication or currently taking second-generation antipsychotics other than clozapine; (4) Capable of cooperating with olfactory assessments, symptom evaluations, and imaging examinations. 2.Control Group: (1)Aged 18 to 45 years; Han ethnicity; right-handed; (2)No history of mental illness and no family history of mental illness within three generations on either side; (3) Normal cognitive function and capable of cooperating with olfactory assessments and imaging examinations.
Exclusion criteria
Exclusion criteria: 1. Patient Group (1)Comorbidity with other mental disorders; (2)Currently undergoing MECT treatment; (3)History of traumatic brain injury, neurological disorders, or severe physical illness; (4)Severe nasal septal deviation, nasal polyposis, or history of nasal surgery; (5)History of respiratory tract infections within the past two weeks; (6)Intellectual disability, dementia, or co-occurring substance dependence and substance abuse; (7)Pregnant or breastfeeding women; (8)Individuals with claustrophobia, metallic implants, or other conditions rendering them unable to tolerate MRI scanning. 2.Control Group (1)History of traumatic brain injury, neurological disorders, or severe physical illnesses; (2)Severe nasal septal deviation, nasal polyposis, or history of nasal surgery; (3)History of respiratory tract infections within the past two weeks; (4)Intellectual disability, dementia, or coexisting substance dependence and substance abuse; (5)Pregnant or breastfeeding women; (6)Individuals unable to tolerate MRI due to conditions such as claustrophobia or the presence of metallic implants.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Odor threshold;Odor recognition;Odor discrimination; | — |
Countries
China
Contacts
Public ContactWentian Dong
Peking University Sixth Hospital
Outcome results
None listed