Non-small cell lung cancer
Conditions
Interventions
Experimental group:Desloratadine
Control group:None
Sponsors
Ningbo Medical Centre Lihuili Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age >= 18 years old and = 3 months; 5.ECOG score 0 or 1; 6.No severe dysfunction of important organs such as the heart, liver, or kidneys; 7.There was at least one radiographically measurable lesion according to the solid tumor efficacy evaluation criteria (RECIST version 1.1); 8.The lesions to be collected within one week prior to the sample collection were not subjected to radiotherapy. 9.Sign a written informed consent before implementing any procedures related to the tria;
Exclusion criteria
Exclusion criteria: 1.Expected survival time <3 months; 2.With known driver gene mutations such as EGFR/ALK/ROS1; 3.Patients with lung metastasis of other primary malignant tumors; 4.With brain metastasis and symptoms present but not receiving effective treatment; 5.Within a week, the affected areas that needed sample collection underwent radiotherapy; 6.Having previously received immunotherapy or any treatment related to the drug under study; 7.Allergic to sorlumab or platinum-based chemotherapy drugs, etc. 8.Companied by severe active infections, diseases of the heart, liver, kidneys and immune and hematopoietic systems; 9.Patients with rare genetic galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption; 10.There was no radiographically measurable lesion according to the solid tumor efficacy evaluation criteria (RECIST version 1.1); 11.Pregnant women or women who are breastfeeding; 12.Subjects with mental disorders who are unable to cooperate with treatment;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Progression free survival;Overall survival;Objective remission rate;Adverse event;Duration of Response (DoR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Histamine level; | — |
Countries
China
Contacts
Public Contactxushuguang
Ningbo Medical Centre Lihuili Hospital
Outcome results
None listed