Alzheimers disease
Conditions
Interventions
Gold Standard:The combined interpretation results for ARIA-E (edema) and ARIA-H (microhemorrhage) by clinical experts based on MRI images (SWI, FLAIR sequences, etc.) were obtained through double "bac
Index test:An automated ARIA detection model based on masked self-supervised learning (MAE algorithm), with 3D T1WI, SWI, and FLAIR sequences as inputs, and the presence/absence of ARIA and severity a
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
50 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 50-85 years, both genders eligible; 2. Confirmed diagnosis of AD/MCI according to NIA-AA clinical diagnostic criteria; 3. Availability of MRI data comprising at least 3D T1WI, SWI, and FLAIR sequences; 4. Eligible for and undergoing DMT novel drug treatment, with multiple follow-up imaging records available.
Exclusion criteria
Exclusion criteria: 1. Patients with other types of dementia or major brain diseases; 2. Presence of severe (treatment-resistant) depression, anxiety, schizophrenia, or other psychiatric disorders, or medical comorbidities that may affect life expectancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall incidence of Amyloid-Related Imaging Abnormalities (ARIA);Sensitivity;Specificity; | — |
Countries
China
Contacts
Public ContactLi Yuxin
Huashan Hospital, Fudan University
Outcome results
None listed