PONV
Conditions
Interventions
Experimental Group (T):Postoperative intravenous injection and patient-controlled analgesia of Tergiline Fumarate
Control group(M):Postoperative intravenous injection and patient-controlled analgesia of Morphine
Sponsors
Liyang People's Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years, female; 2. Non-smoker; 3. ASA classification: I-III; 4. BMI 18.5–25 kg/m^2; 5. Laparoscopic cholecystectomy; 6. Patient informed consent.
Exclusion criteria
Exclusion criteria: 1. Allergy to Tapentadol or morphine; 2. Severe liver and kidney dysfunction (ALT/AST > 2 times the upper limit, Cr > 1.5 times the upper limit); 3. Long-term opioid users who have developed tolerance; 4. Patients with mental illness or cognitive impairment who cannot correctly cooperate with NRS scoring and PCIA operation; 5. Use of prophylactic antiemetics within the past 2 weeks (except for prophylactic drugs specified by the study); 6. Pregnant or breastfeeding women
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative 24h PONV incidence (recording nausea severity NRS score and number of vomiting episodes); | — |
Secondary
| Measure | Time frame |
|---|---|
| NRS score at rest (24h);Record the frequency and total dosage of additional antiemetics and analgesics administered within 24 hours postoperatively, as well as the time of the first request for rescue analgesia and antiemeti;Incidence of common adverse reactions within 24 hours after surgery (respiratory depression, dizziness, somnolence, pruritus, urinary retention); | — |
Countries
China
Contacts
Public ContactKe Zhuang
Liyang People's Hospital
Outcome results
None listed