Trauma-induced coagulopathy
Conditions
Interventions
Intervention group (PCC + FFP):Prothrombin complex concentrate (10–20 IU/kg, adjusted according to coagulation status and bleeding severity) combined with fresh frozen plasma, in addition to standard
Control group (FFP alone):Fresh frozen plasma alone based on clinical requirements, in addition to standard trauma care.
Sponsors
Haining People’s Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Participants must meet all of the following conditions to be eligible for this study: 1. Voluntarily agree to participate in this study and sign the informed consent form. 2. Hospitalized patients aged 18 years or older, of any sex. 3. Patients diagnosed with traumatic coagulopathy, meeting either of the following: (1) Laboratory criteria (any one of the following): 1) PT > 18 s 2) APTT > 60 s 3) TT > 15 s 4) PTr > 1.6 (2) Presence of active or potential bleeding, requiring blood products or replacement therapy.
Exclusion criteria
Exclusion criteria: 1.Patients with cardiac arrest before enrollment; 2.Patients expected to die within 1 hour after admission; 3.Patients transferred from other medical institutions; 4.Patients receiving anticoagulant therapy before injury; 5.Pregnant or lactating women; 6.Known allergy to prothrombin complex concentrate or its components; 7.Participation in another clinical trial within the past 30 days; 8.Any other condition considered unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Total blood product consumption within 48 hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in coagulation parameters;Thromboelastography parameters;Inflammatory markers; | — |
Countries
China
Contacts
Public ContactXiaoxia Li
Haining People’s Hospital
Outcome results
None listed