Knee osteoarthritis
Conditions
Interventions
Esketamine group:Intravenous infusion of esketamine
Normal saline group:Intravenous infusion of normal saline
Sponsors
The Second Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 74 Years
Inclusion criteria
Inclusion criteria: 1.Age range: 60 to 74 years. Both sexes are included. 2.Patients undergoing elective unilateral total knee arthroplasty under general anesthesia. 3.American Society of Anesthesiologists (ASA) physical status classification I-II. 4.18.5kg/m² = BMI < 32.5kg/m².
Exclusion criteria
Exclusion criteria: 1.Patients who decline to participate. 2.Allergic to anesthetics. 3.History or family history of malignant hyperthermia. 4.History of local anesthetic allergy, local skin infection, bleeding at puncture site, etc. 5.Severe coagulation dysfunction. 6.Severe cardiac, pulmonary, hepatic, or renal dysfunction. 7.Severe mental disorders. 8.History of drug addiction or abuse.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of sleep disturbance;postoperative resting pain level; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intraoperative remifentanil consumption;incidence of adverse effects;Frequency of PCIA delivery;Time to extubation; | — |
Countries
China
Contacts
Public ContactRuifeng Zeng
The 2nd Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed