Delirium
Conditions
Interventions
Control group:Placebo was used during anesthesia induction
Esketamine Group:Esketamine was used during anesthesia induction(0.2mg/kg)
Sponsors
The Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged >= 65 years; 2. American Society of Anesthesiologists (ASA) physical status classification Class I–III; 3. Mini-Mental State Examination (MMSE) score > 26; 4. No previous history of psychiatric disease or delirium; 5. Fully informed of the study contents and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Previous history of neurological diseases such as intracranial tumor, cerebral hemorrhage and large-area cerebral infarction, or psychiatric history including depression and dementia; 2. Patients with severe anxiety and depression after surgery, or complicated with severe complications such as pulmonary infection, pulmonary embolism and cerebral infarction; 3. Participation in other ongoing clinical trials or refusal to participate in this study; 4. Mini-Mental State Examination (MMSE) score <= 26 points; 5. Allergy to esketamine or other anesthetic drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Extubation time;PACU stay time;Blood glucose;Lactate;C-reactive protein;Interleukin-6;WBC count;Neutrophil count;Neutrophil percentage; | — |
Countries
China
Contacts
Public ContactAijie Liu
The Affiliated Hospital of Qingdao University
Outcome results
None listed