Toxic Epidermal Necrolysis
Conditions
Interventions
Retrospective cohort of patients with TEN:None
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Participants with a confirmed diagnosis of toxic epidermal necrolysis (TEN). The diagnosis must strictly meet the TEN diagnostic criteria specified in the 2021 Expert Consensus on the Diagnosis and Treatment of Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis, and must be reviewed and confirmed by the research team to exclude misclassification with Stevens-Johnson syndrome (SJS). 2. Disease onset occurred between 2016 and 2026, inclusive. 3. Complete case records are available, including clearly documented disease onset time, suspected triggers such as drug exposure history, diagnostic and treatment process including interventions, clinical outcome including survival or death, and relevant influencing factors such as age, underlying diseases, and SCORTEN score. 4. Cases are from the nationwide multicenter participating medical institutions included in this study. 5. Relevant diagnosis, treatment, and follow-up data are traceable and verifiable, and meet the data collection requirements for a retrospective cohort study.
Exclusion criteria
Exclusion criteria: 1. Cases with clinical manifestations suspected of TEN, but after review by the research team, cannot be clearly confirmed as TEN due to atypical epidermal detachment area or ambiguous clinical features, making it difficult to determine whether TEN was the primary cause of disease onset and death. 2. Cases with incomplete medical records, in which key information such as disease onset time, treatment measures, or clinical outcome is missing or cannot be verified, thereby affecting the accuracy of the research data. 3. Cases complicated by severe end-stage underlying diseases, such as advanced malignant tumors, severe cardiovascular or cerebrovascular diseases, or end-stage renal disease, where the research team confirms that death was clearly caused by the underlying disease and was unrelated to TEN lesions or the TEN diagnosis and treatment process. 4. Cases confirmed by the research team to involve misdiagnosis or missed diagnosis, and therefore not meeting the diagnostic criteria for TEN. 5. Cases lost to follow-up, for which the final clinical outcome (survival or death) cannot be determined despite multiple attempts, including searches of the medical institution's medical record system and telephone follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mortality rate among patients with toxic epidermal necrolysis;Risk factors associated with mortality among patients with toxic epidermal necrolysis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Annual mortality rate among patients with toxic epidermal necrolysis;Regional mortality rate among patients with toxic epidermal necrolysis;Mortality rate according to treatment modality among patients with toxic epidermal necrolysis; | — |
Countries
China
Contacts
Public ContactNingning Dang
Shandong Provincial Hospital
Outcome results
None listed