non-erosive reflux disease
Conditions
Interventions
Part One:None
Part Two:None
Part Three:None
Sponsors
Suining Central Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The first part explores the correlation between different characteristic changes of NERD and reflux. The study subjects were patients diagnosed with NERD at Suining Central Hospital from 2018 to 2026, who had gastroscopy, high-resolution esophageal manometry, and reflux monitoring data. Inclusion criteria: patients diagnosed with NERD, with complete gastroscopy, high-resolution esophageal manometry, and reflux monitoring (24-hour pH monitoring or 24-hour pH combined impedance monitoring) data. Diagnostic criteria for NERD: long disease course (>6 months), reflux-related symptoms, endoscopy findings not corresponding to Los Angeles classification of reflux esophagitis, acid exposure time >4.0%. 2. The second part of the study establishes an AI-assisted NERD diagnostic model. The study subjects were images obtained from the Digestive Endoscopy Center of Suining Central Hospital from 2018 to 2026. Inclusion criteria: images of the gastroesophageal junction that meet upper gastrointestinal endoscopy standards. 3. The third part of the study verifies the diagnostic performance of the model. The study subjects were images obtained from the Digestive Endoscopy Center of Suining Central Hospital after completing parts one and two of the study. Inclusion criteria: patients over 18 years old, referred for upper gastrointestinal endoscopy for screening, gastrointestinal symptom investigation, or monitoring.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for the first part of the study: Poor-quality gastroscopic images of the gastroesophageal junction (GEJ); acid exposure time (AET) < 4.0%; reflux esophagitis (RE); Barrett's esophagus (BE); gastroesophageal outflow obstruction (GOO); eosinophilic esophagitis (EoE); hiatal hernia; history of upper gastrointestinal surgery; malignant esophageal tumors. 2. Exclusion criteria for the second part of the study:Images of the gastroesophageal junction (GEJ) that do not meet the standards of upper gastrointestinal endoscopy. 3. Exclusion criteria for the third part of the study: Pregnancy; malignant esophageal tumors; history of upper gastrointestinal surgery; esophageal stasis; patients with known active upper gastrointestinal bleeding, those undergoing emergency endoscopy, patients with esophageal stricture or severe underlying diseases; patients who refuse to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Detection rate of lesions;24-hour esophageal pH monitoring;Accuracy; | — |
Secondary
| Measure | Time frame |
|---|---|
| high resolution esophageal manometry;twenty-four hours esophageal multiple channel intraluminal pH-impedance reflux monitoring; | — |
Countries
China
Contacts
Public ContactSuYu He
Suining Central Hospital
Outcome results
None listed