Parkinson’s disease
Conditions
Interventions
Real stimulation group :Conventional rehabilitation training
Provide transcranial temporal interference stimulation (tTIS) therapy targeting the subthalamic nucleus (STN).
Sham stimulation group:Conventional rehabilitation training
Use the same electrode placement, treatment environment, and treatment procedure as the real stimulation group.
Sponsors
Suzhou Municipal Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Patients who meet the Diagnostic Criteria for Parkinson’s Disease in China (2016 edition) formulated by the Chinese Medical Association and the Parkinson’s Disease and Movement Disorders Group of the Neurology Branch of the Chinese Medical Doctor Association. 2.Patients with Parkinson’s disease who attend the Department of Rehabilitation Medicine, Department of Neurology, or Department of Neurosurgery of Suzhou Municipal Hospital as outpatients or inpatients. 3.Able to cooperate with study-related assessments, including scale evaluations, electroencephalography (EEG), functional near-infrared spectroscopy (fNIRS), and magnetic resonance imaging (MRI). 4.Willing to keep the original medication regimen basically unchanged during the study period. 5.Voluntarily participate in this study and sign the informed consent form and other relevant study documents.
Exclusion criteria
Exclusion criteria: 1.Patients with cerebrovascular disease, encephalitis, traumatic brain injury, drug-induced parkinsonism, Parkinson-plus syndromes, malignant tumors, epilepsy, or drug/alcohol dependence. 2.Patients with severe cardiac or pulmonary disease, those with sleep disturbances, or those engaged in shift work. 3.Patients currently using dopamine receptor agonists, sedative-hypnotics, or other medications that may affect sleep or interfere with study outcome assessment. 4.Patients unable to cooperate with scale evaluations, imaging examinations, or follow-up visits. 5.Other conditions judged by the investigators to make the patient unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson’s Disease Rating Scale, UPDRS; | — |
Secondary
| Measure | Time frame |
|---|---|
| High-density electroencephalography, EEG;Montreal Cognitive Assessment, MoCA;Parkinson’s Disease Questionnaire-39, PDQ-39;Non-Motor Symptoms Questionnaire, NMSQ;Functional near-infrared spectroscopy, fNIRS;Neuroimaging outcomes; | — |
Countries
China
Contacts
Public ContactYan Gong
Suzhou Municipal Hospital
Outcome results
None listed