Nausea and vomiting after female abdominal surgery
Conditions
Interventions
intervention group:Four hours before the operation, a scopolamine patch (1.5mg/72h) was adhered to the back of the ear through the skin. Before anesthesia induction, 5 mg of dexamethasone and 25 mg of
control group:Four hours before the operation began, placebo patches with the same appearance were applied
5 mg of dexamethasone + normal saline (equal volume) was given intravenously before anesthesia induction
2 mg of tropisetron was given at the end of the operation.
Sponsors
Air Force Characteristic Medical Center
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients aged 18 to 65 years old, with a body mass index (BMI) of >= 18 and = 1 hour ; 4. No history of drug allergies, no contraindications to anesthesia ; 5. Stable vital signs, accompanied by family members during the visit ; 6. Willing to participate in this study and signing the informed consent form for informed consent to this study.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the study drugs (dexamethasone, tropisetron, diphenhydramine, scopolamine); 2. Have a history of angle-closure glaucoma, myasthenia gravis, severe urinary retention, pyloric obstruction or intestinal obstruction; 3. Have used antiemetic drugs, antihistamines or anticholinergic drugs within 24 hours before the surgery; 4. Have a long-term history of taking opioid drugs; 5. Have concurrent severe heart, liver, kidney or other diseases; 6. Have organ damage caused by diabetes and high blood sugar; 7. Have undergone major surgeries recently; 8. Pregnant or lactating women; 9. Have mental disorders or cognitive dysfunction and cannot cooperate with the assessment; 10. Have skin diseases that cannot be adhered to the transdermal patches; 11. Lack self-care ability or are individuals with incomplete behavioral capacity.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative Nausea and Vomiting Score Within 24 Hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of PONV;Record the usage of preventive antiemetic drugs (including the drugs, doses, and times). Record the data of the PCA pump: the total number of effective compressions and the total duration of PCA use. During the 24-hour follow-up after the surgery, inquire about the patient's satisfaction and record any adverse events.; | — |
Countries
China
Contacts
Public ContactLi Jin
Air Force Characteristic Medical Center
Outcome results
None listed