Sarcopenia
Conditions
Interventions
Test group:Dual-mode hip active assistive exoskeleton training (power-assisted walking + hip flexion-extension resistance training)
Control group:Routine geriatric exercise training
Sponsors
The First Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
50 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Aged >=50 years; 2. Meets the AWGS 2025 sarcopenia diagnostic framework, confirmed by low muscle strength (grip strength) and low muscle mass (measured by DXA or BIA); physical performance (5×STS, gait speed) will be recorded according to AWGS 2025 criteria as outcome measures for efficacy and prognosis analysis. 3. Physical performance: Baseline SPPB (0–12 points) will be recorded, and participants will be stratified by SPPB scores (e.g., SPPB 0–6 vs 7–9 vs 10–12) for randomization and subgroup analysis; SPPB score is not used as a diagnostic criterion for sarcopenia. 4. Frailty status: Fried phenotype score 1–3 (pre-frail/frail) or Clinical Frailty Scale (CFS) score 4–6 (mild-to-moderate frailty); CFS assessment will be completed by trained geriatricians/researchers. 5. Able to complete >=10 meters of indoor walking under supervision; 6. Signed informed consent obtained.
Exclusion criteria
Exclusion criteria: Participant-related factors: 1. Severe cognitive impairment with inability to cooperate with study procedures; 2. Participant deemed unsuitable for inclusion at the investigator’s discretion. Condition-related factors: 3. Recent acute cardiovascular or cerebrovascular events; 4. Unhealed fractures, or severe osteoporosis with recent fragility fractures; 5. Severe joint deformity or skin conditions preventing device wear; 6. Severe skin breakdown or open wounds in the device application area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 4-meter walking speed (m/s); | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in Short Physical Performance Battery (SPPB) total score;5-times sit-to-stand test (5×STS);EuroQol Five-Dimensional Five-Level Health Questionnaire(EQ-5D-5L);Timed Up and Go test (TUG) completion time;Grip strength;6-minute walk test distance (6MWT);36-Item Short Form Health Survey (SF-36) quality of life score;Falls Efficacy Scale-International (FES-I) score;World Health Organization Five-Item Well-Being Index (WHO-5) score;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactXu Zherong
The First Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed