Frailty
Conditions
Interventions
Remimazolam group:The initial dose of remimazolam was 0.1 mg/kg administered via infusion for 3 minutes, followed by maintenance infusion at a rate of 0.1–0.5 mg/kg/h.
The initial target plasma conce
Dexmedetomidine group:The initial dose of dexmedetomidine was 0.5 µg/kg infused over 5 minutes, then titrated to 0.5–0.7 µg/kg/h.
The initial target plasma concentration of remifentanil was 2.5 ng/mL
Sponsors
Shanghai Changhai Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly frail patients eligible for bronchoscopy under sedation; 2. Aged >=65 years with an Edmonton Frailty Scale (EFS) score >=6; 3. American Society of Anesthesiologists (ASA) physical status classification grade II–III; 4. Voluntarily participated in the study with informed consent signed by themselves or their family members.
Exclusion criteria
Exclusion criteria: 1. Known allergy or contraindications to the study drugs. 2. Severe cardiac, pulmonary, hepatic and/or renal dysfunction. 3. Pre-bronchoscopic examination with peripheral oxygen saturation (SpO2) 30 kg/m^2. 6. Patients who have participated in other clinical trials within the past 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The QoR-15 score at 24 hours after the operation; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of post-induction hypotension;QoR-15 item scores;Intraoperative hemodynamic variables (HR and MAP);Emergence time;Dosage of vasoactive medications;Rate of sedation interruption;Incidence and dosage of rescue medication;Satisfaction of the operating physician;Postoperative pulmonary complications; | — |
Countries
China
Contacts
Public ContactJinjun Bian
Changhai Hospital
Outcome results
None listed