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Effect of liposomal bupivacaine serratus anterior plane block after minimally invasive coronary artery bypass grafting

Effect of bupivacaine liposome for serratus anterior plane block on early quality of recovery after minimally invasive direct coronary artery bypass grafting

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600125073
Enrollment
Unknown
Registered
2026-05-21
Start date
2026-06-01
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

minimally invasive direct coronary artery bypass grafting

Interventions

Contorl Group :Without ultrasound-guided serratus anterior plane block

Sponsors

The First Affiliated Hospital of Nanjing Medical University / Jiangsu Province Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Elective minimally invasive coronary artery bypass grafting; 2. Age 40–70 years, both genders; 3. ASA physical status class II or III; 4. New York Heart Association (NYHA) functional class II or III; left ventricular ejection fraction (EF) > 50%; 5. Postoperative admission to the ICU; 6. Planned postoperative hospital stay > 24 hours.

Exclusion criteria

Exclusion criteria: 1. Refusal to participate; 2. Contraindications to serratus anterior plane block (thoracic infection; infectious disease or tumor of the skin or soft tissue at the puncture site; unclear or abnormal anatomical location of the puncture site; unclear surface landmarks; coagulation dysfunction; allergy to local anesthetics); 3. Long-term use of chronic analgesic drugs; 4. Inability to understand or complete the Pittsburgh Sleep Quality Index (PSQI) and the 15-item Quality of Recovery (QoR-15) questionnaire; 5. Emergency surgery patients; 6. Severe hepatic or renal insufficiency, chronic obstructive pulmonary disease; 7. Psychiatric disorders or sleep disorders.

Design outcomes

Primary

MeasureTime frame
Pittsburgh Sleep Quality Index (PSQI) scores on preoperative day 1 and on postoperative days 1, 3, and 5;Quality of Recovery-15 (QoR-15) scores at 12 h, 24 h, 48 h, and 72 h postoperatively;

Secondary

MeasureTime frame
Numerical Rating Scale scores for static and dynamic pain (coughing, position changes, etc.) at 12 h, 24 h, 48 h, and 72 h postoperatively;Time of extubation, length of ICU stay, and number of rescue analgesic administrations;

Countries

China

Contacts

Public ContactChen Yu

The First Affiliated Hospital of Nanjing Medical University/ Jiangsu Province Hospital

chenyu_njmu@126.com+86 139 5103 3928

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026