chronic obstructive pulmonary disease
Conditions
Interventions
Experimental group:On the basis of receiving all the above standard conventional treatments, add "personalized high-frequency chest wall oscillation (HFCWO) therapy based on your individual airway res
Control group:On the basis of receiving all of the above standard conventional treatments, add 'using conventional fixed-parameter HFCWO therapy'.
Sponsors
China Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Clear diagnosis: Meeting the GOLD diagnostic criteria for chronic obstructive pulmonary disease (COPD), and hospitalized due to acute exacerbation. 2. Age 40–85 years old, male or female. 3.Capable of spontaneous expectoration; daily sputum volume = 10 mL or sputum is viscous and difficult to discharge. 4. Able to complete pulmonary function or IOS testing within 48 hours after admission, with valid Fres values obtained. 5. No contraindications to HFCWO, able to cooperate with treatment and sputum collection. 6. Sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Existing pneumothorax, mediastinal emphysema, or severe hemodynamic instability. 2. Clear bronchiectasis and combined with macroptysis (> 200 mL/24h). 3. Combined with severe heart failure (NYHA class IV) or unstable arrhythmia. 4. Patients with severe thorax deformity affecting HFCWO treatment after lung resection. 5. Severe consciousness or cognitive impairment, unable to cooperate with the intervention. 6. Participating in other interventional clinical trials. 7. Participants are judged by the investigator or attending physician to be unsuitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Sputum wet weight; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sputum characteristics and rheological indices;Gas exchange indices;Changes in pulmonary function;Clinical symptoms improvement;Treatment tolerance;Adverse Events;Length of hospital stay;Recovery status of acute exacerbation; | — |
Countries
China
Contacts
Public ContactWang Siyuan
China Japan Friendship Hospital
Outcome results
None listed