Peutz Jeghers syndrome
Conditions
Interventions
Sponsors
Beijing Friendship Hospital ,Capital Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: PJ syndrome patients: 1.50 patients with PJS, confirmed by pathology as hamartomatous polyps; 2.or with melanin pigmentation and family history; 3.or STK11 gene positive; 4.Complete data. Patients with benign polyps: 1. mainly common polyps confirmed by pathology; 2. no melanin pigmentation; 3. no family history of PJS. Healthy volunteers: 1. normal physical examination indicators during the same period; 2. No intestinal polyps and related family history.
Exclusion criteria
Exclusion criteria: PJS syndrome patients: 1. Complicated with malignant tumors; 2. History of acute infection or major surgery within the last 2 weeks; 3. Taking hormone or lipid-lowering drugs. Patients with benign polyps:1. other hereditary polyposis (e.g., FAP); 2. Severe hepatic and renal insufficiency; 3. Patients or their family members refused to participate in the study. Healthy volunteers: Patients with hypertension, diabetes, hyperlipidemia and other metabolic diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory markers: platelet count (PLT), platelet-to-lymphocyte ratio (PLR), neutrophil-to-lymphocyte ratio (NLR);Nutritional indicators: total protein (TP), albumin (ALB), hemoglobin (HB);Metabolic indicators: total cholesterol (TC), triglycerides (TG);Area Under the Curve; | — |
Countries
China
Contacts
Public ContactCao Zhenlin
Beijing Friendship Hospital ,Capital Medical University
Outcome results
None listed