postoperative delirium
Conditions
Interventions
taVNS intervention group: The observation group used the vagus nerve stimulator and the disposable stimulation electrode was attached to the distribution area of the auricular branch of the vagus ner
the stimulation parameters were: continuous wave, frequency 20 Hz, pulse width 200 µs, initial current intensity 2 mA, adjusted gradually to 5~8 mA and maintained with the standard of "the patient fee
2.The operation day: the intervention was started 30 minutes before anesthesia induction and continued until 30 minutes after tourniquet deflation after the end of surgery, and the intraoperative stim
3.The first day after surgery: a single intervention was performed in the ward for 30 min with the same current intensity as the first day before surgery.
Control group:The control group wore the same stimulation electrodes and equipment as the observation group, with the same electrode placement position and intervention duration as the observation gro
after the patient reported feeling slight tingling and numbness, the device current output was turned off immediately, without effective electrical stimulation throughout the process, and only the dev
Sponsors
Xuzhou Central Hospital, Southeast University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 65 years, any gender; 2. Scheduled for lower limb orthopedic surgery, with planned use of a tourniquet during surgery; 3. American Society of Anesthesiologists (ASA) classification I–III; 4. Basic normal cognitive function before surgery, MoCA score >= 26, MMSE score >= 24; 5. Patient or their legal representative is fully informed and has signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Preoperative presence of delirium, dementia (MoCA 1.5 or PLT 177 µmol/L), malignant tumors, or systemic active infections.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Occurrence of postoperative delirium (POD);Perioperative and rehabilitation indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| Cognitive function;Serological indicators; | — |
Countries
China
Contacts
Public ContactWang Shuang
Xuzhou Central Hospital, Southeast University
Outcome results
None listed