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Association Between Prophylactic Fresh Frozen Plasma Transfusion and Intraventricular Hemorrhage in Preterm Neonates

Association Between Prophylactic Fresh Frozen Plasma Transfusion and Intraventricular Hemorrhage in Preterm Neonates

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600125060
Enrollment
Unknown
Registered
2026-05-20
Start date
2026-06-10
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Core disease: Intracranial hemorrhage in preterm infants Specific types: Including intracranial hemorrhage, subarachnoid hemorrhage, epidural hemorrhage, intraventricular hemorrhage and choroid plexus hemorrhage.

Interventions

Case group:None
Control group:None

Sponsors

Army Medical Center of PLA
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Preterm infants with discharge diagnosis including intracranial hemorrhage, subarachnoid hemorrhage, epidural hemorrhage, intraventricular hemorrhage, or choroid plexus hemorrhage; 2. Preterm infants with gestational age 70 s within 24 hours after birth; 4. Complete clinical data (including plasma transfusion records, cranial ultrasound findings, laboratory parameters, etc.).

Exclusion criteria

Exclusion criteria: 1. those with missing key baseline data (e.g., gender, birth weight, gestational age) exceeding 30%; 2. those with completely missing major laboratory data during hospitalization (e.g., initial routine blood test, coagulation function on admission); 3. those with confirmed IVH at birth (verified by cranial ultrasound) or severe congenital neurological malformations (e.g., spina bifida, cerebral hypoplasia); 4. those with inherited metabolic diseases or severe cardiopulmonary malformations (e.g., congenital heart disease, diaphragmatic hernia); 5. those for whom treatment was withdrawn or who died within 3 days of hospitalization due to severe infection, shock, or other causes.

Design outcomes

Primary

MeasureTime frame
Occurrence of Intracranial Hemorrhage;

Countries

China

Contacts

Public ContactPeng Wenjie

Army Medical Center of PLA

pengwenjie@tmmu.edu.cn+86 23 68710291

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026