Stroke
Conditions
Interventions
Sequence 1:Based on conventional rehabilitation therapy, interventions are carried out in the following order: sham stimulation - washout period - 10Hz tACS - washout period - 20Hz tACS - washout peri
Sequence 2:Based on conventional rehabilitation therapy, interventions are carried out in the following order: 10Hz tACS - washout period - 20Hz tACS - washout period - personalized ß-tACS - washout p
Sequence 3:Based on conventional rehabilitation therapy, interventions are carried out in the following order: 20Hz tACS - washout period - personalized ß-tACS - washout period - sham stimulation - wa
Sequence 4:Based on conventional rehabilitation therapy, interventions are carried out in the following order: personalized ß-tACS - washout period - sham stimulation - washout period - 10Hz tACS - wa
Sponsors
Shanghai Seventh People’s Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
45 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 45–75 years old, gender not limited, normal vision or corrected vision; 2. Meets the diagnostic criteria of the "Diagnostic Criteria for Integrated Traditional Chinese and Western Medicine of Cerebral Infarction and Cerebral Hemorrhage (Trial)" in 2006 and is confirmed by head CT or MRI examination; 3. First onset of unilateral hemiplegia accompanied by upper limb motor dysfunction; 4. Disease duration >= 3 months, condition stable, vital signs stable; 5. Can sit independently for 30 minutes or more; 6. Clear consciousness, no aphasia or hemineglect, able to understand scale content and cooperate with examination and treatment; 7. MMSE >= 24, years of education >= 6 years; 8. Can detect MEP amplitude and latency; 9. Brunnstrom stage of the hemiplegic upper limb is stage III or above, and modified Ashworth grade is below grade 2; 10. Voluntarily sign the informed consent form and understand the research content.
Exclusion criteria
Exclusion criteria: 1. Those with critical conditions or whose conditions in the acute stage have not yet stabilized; 2. Diagnosing patients with any other neurological diseases; 3. Those who have conditions such as deafness, aphasia or severe cognitive impairment, making it difficult for them to communicate normally; 4. Patients with severe primary diseases of the cardiovascular, liver and other systems, mental patients, patients with malignant tumors, patients with venous thrombosis, osteoporosis, patients with severe bleeding tendency and patients with infection at the treatment site; 5. Those who are unable to cooperate with this research protocol for rehabilitation; 6. Those who participate in other clinical trials simultaneously; 7. Inability to understand or sign the informed consent form; 8. There are any contraindications to tACS, EEG, EMG or TMS, such as the placement of cardiac pacemakers, cochlear implants, metal implants in the brain and other equipment; 9. Other circumstances where the researcher deems it inappropriate to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Amplitude and latency of motor evoked potential;Corticomuscular coherence; | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting motor threshold;Central motor conduction time;Power spectral density;Event-related spectral perturbation;Event-related synchronization and de-synchronization;ß- rebound intensity;Root mean square electromyography;Median frequency;Integrated electromyography value;Synergistic contraction rate;Intermuscular coherence;Phase lock value;Transfer entropy;Granger causality test; | — |
Countries
China
Contacts
Public ContactYu Xiaoming
Shanghai Seventh People’s Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed