rheumatoid arthritis
Conditions
Interventions
Methotrexate combined with eramimod group:None
Methotrexate combined with adalimumab group:None
Methotrexate combined with tofacitinib group:None
Healthy control group:None
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. All patients met the diagnostic criteria for rheumatoid arthritis established by the 2010 ACR/EULAR, 2. Age >= 18 years, both male and female, 3. Using MTX 10–20 mg/week for >= 8 weeks and DAS28 score >= 3.2, 4. Have not used bDMARD/tsDMARD.
Exclusion criteria
Exclusion criteria: 1.Patients with other connective tissue diseases, 2.Patients with cardiovascular risk and liver and kidney dysfunction, 3.Patients with serious infections, malignant tumors, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| tender joints count;swollen joints count;evaluator’s global assessment;patient’s global assessment;visual analogue scale;health status assessment questionnaire;erythrocytesedimentation rate;C-reactive protein;rheumatoid factor;white blood cell count;red blood cell count;hemoglobin;platelet count;aspartate aminotransferase;alanine aminotransferase;creatinine; | — |
Countries
China
Contacts
Public ContactPeng Yuanhong
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed