Negative Emotions
Conditions
Interventions
Control group:After the end of the experiment, a 5 ml intravenous bolus of normal saline was administered
Low-dose esketamine group:Esketamine injection at a dose of 0.2 mg/kg is drawn up, diluted with normal saline to 5 ml, and administered as a slow intravenous bolus over 5 minutes by an anesthesiologis
High-dose esketamine group:Esketamine injection at a dose of 0.4 mg/kg is drawn up, diluted with normal saline to 5 ml, and administered as a slow intravenous bolus over 5 minutes by an anesthesiologi
Sponsors
Plastic Surgery Hospital, Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age >=18 years old, regardless of gender; 2) Patients who plan to undergo elective surgery in the craniomaxillofacial plastic surgery department of our hospital and need hospitalization; 3) American Society of Anesthesiologists grade I-III; 4) Have clear consciousness, normal cognition and communication skills, can understand the content of this study and complete the scale evaluation; 5) Volunteer to participate in this study and sign written informed consent.
Exclusion criteria
Exclusion criteria: 1) Patients with known allergy to esketamine; 2) Patients with uncontrolled hypertension (systolic blood pressure > 180 mmHg or diastolic blood pressure > 110 mmHg) or severe cardiovascular disease (e.g., unstable angina, recent myocardial infarction, severe heart failure); 3) Patients with a history of increased intracranial pressure, cerebral aneurysm, cerebral hemorrhage or traumatic brain injury; 4) Patients with a history of schizophrenia, bipolar disorder or other serious mental illness; 5) Those with a history of drug abuse or long-term alcohol abuse;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative anxiety and depression status;Postoperative Quality of Recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain;Sleep score;Hemodynamics;Postoperative Nausea and Vomiting; | — |
Countries
China
Contacts
Public ContactWang Qianyu
Plastic Surgery Hospital, Chinese Academy of Medical Sciences
Outcome results
None listed