Hypertrophic cardiomyopathy
Conditions
Interventions
HCM group:None
Control group:None
Sponsors
Shanghai Tenth People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. The diagnostic criteria for HCM were: (1) asymmetric left ventricular hypertrophy with a maximal wall thickness =15 mm and a thickness ratio (affected segment/inferior wall) >1.5; or a wall thickness =13 mm in individuals with a positive family history or causative genetic mutation.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria included: Myocardial hypertrophy secondary to other causes (e.g., infiltrative cardiomyopathies such as amyloidosis or Fabry disease); 2. Inflammatory cardiomyopathy; 3. Coronary artery disease; 4. Uncontrolled hypertension; 5. Aortic valve disease; 6. Post-ablation therapy for HCM; 7. Allergy to contrast agents; 8. Claustrophobia; 9. Inadequate image quality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Left ventricular kinetic energy (KE) and hemodynamic flow component parameters;Late gadolinium enhancement (LGE);Major adverse cardiovascular events (MACE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Left ventricular functional parameters (indexed end-diastolic volume, indexed end-systolic volume, stroke volume, ejection fraction);In-plane left ventricular kinetic energy (in-plane KE);Time delay (TD) of blood flow propagation;Flow component parameters (direct flow, retained flow, delayed ejection flow, stagnant flow, and their corresponding kinetic energy);Pre-contrast myocardial T1 value;Extracellular volume fraction (ECV); | — |
Countries
China
Contacts
Public ContactPeng Kun
Shanghai Tenth People's Hospital
Outcome results
None listed