Acute kidney injury after cardiac surgery with cardiopulmonary bypass
Conditions
Interventions
Control Group:Conventional Perfusion
Goal-directed perfusion group:Maintain DO2i>280mL/min/m ^ 2
Sponsors
Zhongshan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >= 18 years; 2. Patients undergoing elective conventional open thoracotomy cardiac valve surgery under cardiopulmonary bypass; 3. Intermediate-to-high risk according to the preoperative ACEF score; 4. Written informed consent signed by the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Patients with CKD stage 5 or undergoing renal replacement therapy; 2. Pre-existing acute kidney injury; 3. Pregnant women; 4. History of nephrectomy; 5. History of kidney, liver, heart, or lung transplantation; 6. Patients with severe infection or sepsis; 7. Emergency surgery or time-limited surgery; 8. Expected requirement for circulatory arrest during operation; 9. Participation in other clinical trials that may interfere with the results of this study; 10. Preoperative hemodynamic instability requiring high-dose vasoactive agents (e.g., norepinephrine > 0.1 µg/kg/min) or intra-aortic balloon pump (IABP) support.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of Acute Kidney Injury; | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of Postoperative Mechanical Ventilation;Length of ICU Stay;Total Length of Hospital Stay;Occurrence of the Composite Outcome of Myocardial Infarction, Stroke, or Death; | — |
Countries
China
Contacts
Public ContactSun Pan
Zhongshan Hospital, Fudan University
Outcome results
None listed