Prolonged disorders of consciousness
Conditions
Interventions
The second phase:None
Sponsors
Guangdong Provincial Second Hospital of Traditional Chinese Medicine (The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine)
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–80 years; 2. Patients with impaired consciousness following severe acquired brain injury, including traumatic brain injury, stroke, hypoxic-ischemic brain injury, postoperative brain injury, encephalitis, or other non-degenerative structural brain injuries; 3. Vital signs are relatively stable, and the patient is capable of completing two independent CRS-R assessments and routine EEG recordings; 4. A legal representative is available to sign a written informed consent form; 5. Expected to be able to complete the study protocol by the time of the baseline assessment.
Exclusion criteria
Exclusion criteria: 1. Persistent deep sedation, general anesthesia, or uncontrolled status epilepticus during the scheduled assessment window; 2. Hemodynamic or respiratory instability that precludes the safe completion of a bedside assessment or EEG examination; 3. Concurrent severe failure of a major organ, or a life expectancy of less than 2 weeks as determined by the investigator; 4. Severe uncorrected bilateral visual or hearing impairment that prevents the administration of standardized behavioral assessments; 5. History of confirmed neurodegenerative disease, severe developmental disorders, or other conditions that significantly affect the interpretation of the CRS-R; 6. Other circumstances deemed inappropriate for enrollment by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Consistency between AI-predicted CRS-R total scores and the expert-adjudicated gold standard reference; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Absolute Error (MAE) of AI-predicted CRS-R total scores;Diagnostic accuracy of the AI model for categorical state of consciousness (UWS/MCS/EMCS); | — |
Countries
China
Contacts
Public ContactChi Xiangfeng
Guangdong Provincial Second Hospital of Traditional Chinese Medicine (The Fifth Clinical Medical College of Guangzhou University of Chinese Medicine)
Outcome results
None listed