None
Conditions
Interventions
High pressure group:Drving presuure 1.1 bar
Low pressure group:Drving presuure 0.7 bar
Medium pressure group:Drving presuure 0.9 bar
Sponsors
Emergency General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Age: 18 to 60 years old, gender unrestricted. 2. ASA classification I–III; 3. It is planned to perform mediastinal or hilar lymph node puncture biopsy under general anesthesia via rigid bronchoscopy. 4. Preoperative imaging studies (chest CT) indicated that the trachea and main bronchi were unobstructed, with no significant space-occupying lesions or severe stenosis (lumen stenosis = 30 minutes and the duration of jet ventilation is >= 20 minutes, the measurements at each set time point can be completed. 6. Preoperative bedside or pre-assessment ultrasound can clearly display the image of the inferior vena cava (IVC) and complete the measurement of CTI. 7. The patient or his/her legal representative has signed the informed consent form for anesthesia and the informed consent form for the study.
Exclusion criteria
Exclusion criteria: 1. Those with obvious main airway occupation or severe stenosis (tracheal or main bronchial stenosis >= 30%), who need to rely on high-pressure jet or special ventilation strategies to maintain ventilation; 2. Severe underlying pulmonary diseases that may significantly affect the effect of jet ventilation or the transmission of intrathoracic pressure, such as: severe COPD, severe emphysema or pulmonary bullae, active severe pulmonary infection, pulmonary fibrosis and interstitial lung disease, respiratory failure, etc. 3. Cardiovascular diseases that have a significant impact on the anatomy or hemodynamic interpretation of the inferior vena cava, including but not limited to: moderate to severe right heart failure, significant pulmonary hypertension, severe tricuspid regurgitation, previous history of inferior vena cava filter implantation or inferior vena cava surgery. 4. There were obvious volume intervention factors before the operation that might affect the interpretation of the baseline CTI: rapid or large-volume fluid infusion (>10 mL/kg) within 6 hours before the operation; use of large doses of vasoactive drugs; 5. BMI >= 35 kg/m^2 or other reasons causing difficulty in ultrasound imaging of the inferior vena cava, and reliable CTI data cannot be obtained. 6. Those who need to temporarily change the ventilation mode due to changes in the condition during the operation and thus cannot complete the pre-determined research process; 7. In the course of the research, if serious adverse events occur (such as persistent hypoxia, severe hypotension, barotrauma, etc.) and the researcher deems that continuing the research may endanger the patient's safety.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inferior vena cava collapse index at T3; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of intraoperative adverse events;Arterial blood gas indicators;Hemodynamic indicators;The inferior vena cava collapse index at other time points; | — |
Countries
China
Contacts
Public ContactMingyuan Yang
Emergency General Hospital
Outcome results
None listed