major depressive disorder
Conditions
Interventions
Elderly Major Depression Group:none
Healthy control group:none
Sponsors
Hangzhou Seventh People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patient enrollment criteria: (1) Currently meet the DSM-V diagnostic criteria for major depressive disorder; (2) Age > 60 years old; (3) Voluntarily join this study, understand the research content, and sign the informed consent form. 2. Normal control enrollment criteria: (1) Currently and previously do not meet any of the DSM-V diagnostic criteria for any mental disorders; (2) Obtain written informed consent from the participant or their legal guardian; (3) Age > 60 years old.
Exclusion criteria
Exclusion criteria: 1. Patient exclusion criteria: (1) Neurological diseases; mental disorders caused by organic brain disorders and somatic diseases; (2) Other severe mental disorders meeting DSM-V diagnostic criteria (including IQ <=70 or mental retardation, other neurodevelopmental disorders, schizophrenia, bipolar disorder, etc.); (3) Use, abuse, or dependence on psychoactive substances other than tobacco and alcohol; (4) Currently suffering from active somatic diseases that significantly affect diagnosis and treatment. 2. Normal control exclusion criteria: (1) Family history of mental disorders within two generations; (2) Neurological diseases; (3) Use of benzodiazepines within the past 6 months; (4) Currently suffering from significant active somatic diseases; (5) Unable to complete relevant tests;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical scale data (including MMSE, GAD-7, PHQ-9, PHQ-15, MDQ, HAMA, HAMD-17, Life Events Scale, Family System Dynamics Scale, etc.); | — |
Secondary
| Measure | Time frame |
|---|---|
| Electroencephalogram data;3DT1 of cranial structure (sMRI), diffusion tensor imaging data (dMRI), resting-state functional MRI data (fMRI); | — |
Countries
China
Contacts
Public ContactTang Guangzheng
Hangzhou Seventh People's Hospital
Outcome results
None listed