Irritable Bowel Syndrome
Conditions
Interventions
H.pylori-positive group:N/A
H.pylori-negative group:N/A
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Outpatients who visited our hospital (Department of Gastroenterology or Physical Examination Center) from January 1, 2017 to December 31, 2021 and have complete electronic medical records (EMR). 2. Aged between 18 and 75 years at the time of visit. 3. Within the above time frame, there must be a clear Helicobacter pylori (H. pylori) test result. The date of this confirmed test result is defined as the "index date (T0)". 4. Adequate follow-up period: in the EMR system, from T0 onwards, there must be at least 1 year of follow-up or return visit records (up to January 2024); 5.No gender restriction.
Exclusion criteria
Exclusion criteria: 1. Before T0, patients who already had a clear diagnosis of "Irritable Bowel Syndrome (IBS)" or "chronic diarrhea" in their electronic medical records, or had long-term records of taking antidiarrheal drugs (such as diosmectite powder, loperamide) or antispasmodics (such as pinaverium bromide); 2. Within 1 year (365 days) after T0, patients whose medical records first show IBS-D-like symptoms or chronic diarrhea; 3. Patients who, within 4 weeks before T0, used systemic antibiotics due to other infectious diseases, or took microbiota preparations (probiotics); 4. Patients with a clear diagnosis of inflammatory bowel disease (IBD, including Crohn's disease and ulcerative colitis), microscopic colitis, celiac disease, or colorectal malignancy; 5. Patients who had previously undergone major gastrointestinal surgery (such as gastrectomy, intestinal resection, or cholecystectomy); 6. Patients with known systemic diseases that can cause chronic diarrhea, such as hyperthyroidism, or diabetes with severe autonomic neuropathy; 7. Patients who did not provide recent colonoscopy results (within 1-2 years before or after symptom onset) to exclude organic diseases of the lower gastrointestinal tract (mandatory for patients aged > 40-50 or with alarm symptoms).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The Occurrence of Irritable Bowel Syndrome (IBS) or IBS-like syndrome; | — |
Secondary
| Measure | Time frame |
|---|---|
| IBS Severity Scoring System;Birmingham IBS Symptom Questionnaire;Short Form Nepean Dyspepsia Index(SF-NDI);Fatigue Assessment Scale (FAS) Score;Percentage of Bristol stool form scale 6-7; | — |
Countries
China
Contacts
Public ContactZhou Xiaoying
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed