Lung cancer
Conditions
Interventions
Bidirectional Cohort of Patients Undergoing Radical Lung Cancer Resection:None
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years old; 2. Pathologically confirmed NSCLC or SCLC with clinical stage I-III; 3. Underwent radical surgery (lobectomy/segmentectomy) in Peking University Shenzhen Hospital from Jan 1, 2020 to Dec 31, 2025; 4. Frozen cancer tissue (>=1cm³) available at surgery; 5. Able to complete questionnaires and follow-ups; 6. Patient or legal representative signs informed consent.
Exclusion criteria
Exclusion criteria: 1. COVID-19 diagnosis within 6 months before surgery ; 2. Preoperative chemotherapy, radiotherapy, targeted or immunotherapy ; 3. Preoperative neoadjuvant/adjuvant therapy with immune checkpoint inhibitors (PD-1/PD-L1, etc.); 4. Comorbid with other malignancies or severe cardiopulmonary diseases ; 5. Cognitive impairment preventing cooperation; 6. Unable to contact or confirmed lost to follow-up ; 7. Explicit refusal to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 5-year PCC incidence;5-year OS;5-year PFS; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of Postoperative Grade >=3 Adverse Events;Quality of Life Score (EORTC QLQ-C30);5-year Recurrence Rate;Incidence of Acute COVID-19 Infection; | — |
Countries
China
Contacts
Public ContactXu Junjie
Peking University Shenzhen Hospital
Outcome results
None listed