Acute cerebral infarction
Conditions
Interventions
Early use of aspirin group:Early use of aspirin after rt-PA thrombolysis
Control group:Conventional treatment
Sponsors
Beijing Chao-Yang Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-70 years (inclusive); 2. Onset within 3 hours (inclusive); 3. Duration of neurological deficit exceeds 1 hour; 4. NIHSS > 1 point; 5. CT excludes cerebral hemorrhage, and there are no imaging changes corresponding to the patient's signs.
Exclusion criteria
Exclusion criteria: 1. Age > 70 years; 2. Time of onset > 3 hours; 3. Accompanied by consciousness disturbance, or NIHSS >= 10 points; 4. CT shows "hyperdense middle cerebral artery"; 5. Accompanied by atrial fibrillation or clearly cardioembolic (e.g., history of rheumatic heart disease); 6. Severe swallowing difficulty, unable to take oral medication; 7. Currently taking anticoagulants; 8. Accompanied by severe infection or evidence of severe infection (high fever); 9. Systolic blood pressure > 160 mmHg and difficult to control; 10. Immediate blood glucose >= 10 mmol/L; 11. Patients with gastrointestinal bleeding or active gastric or duodenal ulcer; 12. Other conditions deemed unsuitable for study participation by the investigator; 13. Refusal to sign the informed consent for the study. Also meeting the exclusion criteria for traditional intravenous thrombolysis: 1. Previous intracranial hemorrhage, head trauma within the past 3 months, gastrointestinal or urinary system bleeding within the past 3 weeks, major surgery within the past 2 weeks; 2. History of cerebral infarction or myocardial infarction within the past 3 months; 3. Severe heart, liver, kidney dysfunction, or severe diabetes; 4. Evidence of active bleeding or trauma; 5. Thrombocytopenia; 6. Blood pressure > 180/100 mmHg; 7. Pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The good prognosis at 3 months, i.e. the proportion of mRs score 0-2.; | — |
Secondary
| Measure | Time frame |
|---|---|
| incidence of symptomatic intracranial hemorrhage;Patient mortality rate at 3 months; | — |
Countries
China
Contacts
Public ContactLu Ming
Beijing Chao-Yang Hospital, Capital Medical University
Outcome results
None listed