Thyroid Nodules
Conditions
Interventions
Sequential Method Dose Group:Using a sequential method based on a biased coin design, mivacurium was continuously infused during anesthesia maintenance for thyroid surgery to determine the appropriate
Sponsors
The Fifth Affiliated Hospital of Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily signs the informed consent form; 2.Study participants aged 18-65, with ASA physical status I-II, BMI 18.5-24.9, regardless of gender; 3.Study participants scheduled to undergo thyroid surgery under general anesthesia; 4.Study participants for whom the use of intraoperative neuromonitoring is planned.
Exclusion criteria
Exclusion criteria: 1.Study participants with known or suspected homozygous atypical plasma cholinesterase genotype, or those with reduced plasma cholinesterase activity; 2.Those with neuromuscular diseases or using medications that affect neuromuscular transmission; 3.Study participants with asthma; 4.Study participants who are lactating or pregnant; 5.Those with preoperative recurrent laryngeal nerve injury or vocal cord dysfunction identified by laryngoscopy; 6.Study participants who are allergic or have contraindications to the drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Electromyographic Signal Amplitude; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mean Arterial Pressure;Incidence of Recurrent Laryngeal Nerve Injury;QoR-15 Score;Lowest monitoring value of neuromuscular transmission; | — |
Countries
China
Contacts
Public ContactYing Wang
The Fifth Affiliated Hospital of Sun Yat-Sen University
Outcome results
None listed