Acute pain after craniotomy
Conditions
Interventions
Control group:Scalp nerve block with 0.5% bupivacaine hydrochloride
Experimental group:Scalp nerve block with 0.25% bupivacaine hydrochloride combined with 0.67% liposomal bupivacaine
Sponsors
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years and <= 75 years; 2. American Society of Anesthesiologists (ASA) physical status classification ?~?; 3. Scheduled for supratentorial craniotomy; 4. Informed consent obtained from the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Preoperative Glasgow Coma Scale (GCS) score < 15; 2. Predicted to require sedation, unable to extubate, or at high risk of extubation difficulty requiring mechanical ventilation support postoperatively; 3. Unable to understand the Quality of Recovery-15 (QoR-15) scale and Numerical Rating Scale (NRS) for pain assessment; 4. History of allergy or contraindication to amide local anesthetics, opioids, or non-steroidal anti-inflammatory drugs (NSAIDs); 5. Long-term treatment with opioids or corticosteroids for more than 2 weeks; 6. History of drug abuse or addiction within the past 2 years; 7. Daily alcohol consumption exceeding 3 standard doses (˜10g alcohol, equivalent to 50g Chinese high-alcohol liquor); 8. Presence of mental or cognitive disorders that may interfere with perioperative assessment; 9. Contraindications to nerve block, including infection or tumor at the puncture site, confirmed diabetic peripheral neuropathy, and inability to cooperate; 10. Patients with severe liver insufficiency (Child-Pugh Class C), severe renal insufficiency (requiring dialysis before surgery), or severe heart failure (METS < 4); 11. Pregnant or lactating women; 12. Craniotomy incision beyond the area covered by scalp nerve block; 13. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of Recovery-15 (QoR-15) score assessed at 48 hours after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Usage of analgesics;Nausea and vomiting incidence rate; | — |
Countries
China
Contacts
Public ContactXin Jihua
Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine
Outcome results
None listed