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Effect and Prognosis Model of TMS-tDCS Combined Intervention on Adolescent Refractory Depression Based on EEG Microstate Analysis

Effect and Prognosis Model of TMS-tDCS Combined Intervention on Adolescent Refractory Depression Based on EEG Microstate Analysis

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124905
Enrollment
Unknown
Registered
2026-05-19
Start date
2026-08-01
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depression

Interventions

Combined group (electrical + magnetic):tDCS+rTMS
Single magnetic stimulation group:Only received rTMS treatment with the same parameters.
Single magnetic stimulation group:Only received tDCS treatment with the same parameters.

Sponsors

Shandong Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
12 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1.Patients aged 12-60 with treatment-resistant depression (TRD);

Exclusion criteria

Exclusion criteria: 1.Patients with contraindications to TMS (such as a history of epilepsy or intracranial metal implants); 2.patients with serious physical illnesses (such as heart failure grade III or above); 3.or patients who have recently received electroconvulsive therapy (ECT) within the past 3 months.

Design outcomes

Primary

MeasureTime frame
Hamilton Depression Scale (HAMD-17) score;EEG assessment;—

Secondary

MeasureTime frame
Fimde Behavior Activity Rating Scale (RBANS) score;Clinical response rate (HAMD reduction of >=50%);Columbia Suicide Severity Rating Scale (C-SSRS) score;—

Countries

China

Contacts

Public ContactZhu Jianlei

Shandong Mental Health Center

532007403@qq.com+86 531 86336621

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026