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Study on the differences and risk prediction of liver-vascular multimodal indicators in patients after cardiovascular and cerebrovascular events, metabolic high-risk groups, and healthy individuals using quantitative ultrasound

Study on the differences and risk prediction of liver-vascular multimodal indicators in patients after cardiovascular and cerebrovascular events, metabolic high-risk groups, and healthy individuals using quantitative ultrasound

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2600124900
Enrollment
Unknown
Registered
2026-05-19
Start date
2026-05-19
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Myocardial infarction

Interventions

Gold Standard:Magnetic Resonance Imaging Proton Density Fat Fraction (MRI-PDFF)
Index test:Multimodal quantitative ultrasound (including: acoustic attenuation imaging (USAT) to measure acoustic attenuation coefficient (ATT)
Shear wave elastography (SWE) is used to measure liver hardness
High resolution B-mode ultrasound measurement of carotid intima-media thickness (cIMT)
Vector Flow I

Sponsors

Tongji Hospital of Tongji University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Patient group after cardiovascular and cerebrovascular events: (1) Age range of 18-75 years old; (2) Meets the WHO diagnostic criteria for ischemic cardiovascular and cerebrovascular events (myocardial infarction/ischemic stroke/coronary or carotid revascularization), and the last event occurred between 1 and 12 months ago; (3) Presence of metabolic abnormalities. 2. Metabolic abnormality event free group: (1) Age range of 18-75 years old; (2) Meets the diagnostic criteria for metabolic syndrome; (3) No history of cardiovascular or cerebrovascular events (no history of myocardial infarction, stroke, TIA, or revascularization). 3. Healthy control group: (1) Age range of 18-75 years old; (2) No confirmed metabolic disease (diabetes/fatty liver, etc.) and cardiovascular disease history, and no relevant drug treatment history in the past year.

Exclusion criteria

Exclusion criteria: 1. Patient group after cardiovascular and cerebrovascular events: (1) Cirrhosis (SWE >= 10 kPa), liver cancer, or Child-Pugh B/C liver disease; (2) Severe heart failure (NYHA III-IV grade) or renal failure (eGFR = 0.60 dB/cm/MHz) or carotid artery cIMT >= 0.9 mm.

Design outcomes

Primary

MeasureTime frame
Carotid wall shear stress (WSS);Carotid intima-media thickness (CIMT);Liver sound attenuation coefficient (ATT);Liver shear wave elastic hardness (SWE);Sensitivity;specificity;—

Secondary

MeasureTime frame
Blood biochemical indicators (blood lipids, blood glucose, liver enzymes, etc.);Vital signs (respiration, pulse);Magnetic resonance proton density fat fraction (mri-pdff);—

Countries

China

Contacts

Public ContactZhang Bing, Bai Wenkun

Tongji Hospital of Tongji University

doctor505@hotmail.com+86 21 6611 2062

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026