Hypertrophic Obstructive Cardiomyopathy
Conditions
Interventions
Experimental Group:Bipolar percutaneous Endocardial Septal Radiofrequency Ablation
Sponsors
Chinese Academy of Medical Sciences Fuwai Hospital
Eligibility
Sex/Gender
All
Age
15 Years to 85 Years
Inclusion criteria
Inclusion criteria: (1) Patients aged 18-85 with symptomatic HOCM; (2) Patients who are not suitable for surgical procedures or who subjectively refuse surgical procedures; (3) Patients who do not have suitable coronary vessels for chemical ablation or who subjectively refuse chemical ablation; (4) Resting or provoked left ventricular outflow tract transvalvular pressure gradient =50mmHg; (5) Cardiac ultrasound excludes giant papillary muscles or the presence of abnormal muscle bundles; (6) Patients who agree to be enrolled and can complete follow-up on time.
Exclusion criteria
Exclusion criteria: (1) Patients with abnormal muscle bundles (false tendons, hypertrophic papillary muscles, etc.) indicated by transthoracic echocardiography; (2) Patients with isolated hypertrophic cardiomyopathy (HOCM); (3) Patients with HOCM accompanied by ventricular dilation or heart failure; (4) Patients with concomitant malignancy or life expectancy less than 1 year; (5) Patients who are not suitable for surgery during the acute phase of the disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The decrease proportion of LVOTG after 3 months of surgery compared to before proceduree; | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement in NYHA functional classification;Syncope/pre-syncope relief rate;Interventricular septal thickness;Proportion of patients transferred to surgical department for septal resection;Permanent pacemaker implantation rate;Bundle branch block;Cardiac tamponade;Complications of vascular puncture;All cause mortality; | — |
Countries
China
Contacts
Public ContactJia Yuhe
Chinese Academy of Medical Sciences Fuwai Hospital
Outcome results
None listed