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Changes in Cognitive Control Function in Schizophrenia Patients Following Theta-Burst Stimulation (TBS) Intervention: A TMS-EEG Study

Changes in Cognitive Control Function in Schizophrenia Patients Following Theta-Burst Stimulation (TBS) Intervention: A TMS-EEG Study

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600124894
Enrollment
Unknown
Registered
2026-05-19
Start date
2025-03-13
Completion date
Unknown
Last updated
2026-05-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Schizophrenia

Interventions

Active Stimulation Group:Theta Burst Stimulation
Sham Stimulation Group:Theta Burst Stimulation using a sham stimulation coil
Healthy Control Group:none

Sponsors

Hebei Mental Health Center
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18–60 years, right-handed, regardless of gender; 2. Diagnosis of schizophrenia according to ICD-10; 3. Disease duration of less than 5 years; 4. At least primary school education and able to cooperate with testing; 5. Scores of P1, P6, and P7 on the PANSS scale <= 4, total PANSS score <= 70, and stable dosage of antipsychotic medication; 6. Voluntary participation in the study and signed informed consent.

Exclusion criteria

Exclusion criteria: 1. Comorbidity with other psychiatric disorders; 2. Psychotic conditions caused by other systemic diseases or organic brain lesions; 3. History of cranial diseases, brain injury, epileptic seizures, or other neurological disorders; 4. History of severe systemic diseases, including those of the cardiovascular, respiratory, and immune systems; 5. History of alcohol or opioid abuse; 6. Presence of metallic implants in the body, such as dentures, arterial clips, pacemakers, or metal fixators.

Design outcomes

Primary

MeasureTime frame
TMS Evoked Potential;EEG Functional Connectivity;

Countries

China

Contacts

Public ContactJie Wang

Hebei Mental Health Center

gessen_01@163.com+86 158 3123 7900

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 30, 2026