Mild cognitive impairment
Conditions
Interventions
Tai Chi instructor (Phase 1):None
MCI older adults (Phase 1):None
Cognitive-enhanced seated Tai Chi group (Phase 2):Cognitive-enhanced seated Tai Chi program: 12 weeks, 3 times per week, 60 minutes per session, total of 36 sessions
group instruction with approximately 4–5 participants per group
based on adapted seated movements from the 24-form simplified Tai Chi, systematically integrated with graded cognitive tasks.
Seated stretching exercise control group (Phase 2):Seated stretching exercise program: 12 weeks, 3 times per week, 60 minutes per session
course structure similar to the trial group, but without any formal cognitive training components.
Sponsors
Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: Stage 1: Participatory co-design phase (1) Age = 60 years; (2) Diagnosed with mild cognitive impairment according to the Petersen criteria after professional assessment [4], with a Montreal Cognitive Assessment (MoCA) score of 18–25. Stage 2: Pilot randomized controlled trial phase (1) Age = 60 years; (2) Diagnosed with mild cognitive impairment according to the Petersen criteria after professional assessment [4], with a Montreal Cognitive Assessment (MoCA) score of 18–25; (3) Owns a smartphone and has internet access, and is able to participate in online courses via Tencent Meeting with family assistance; (4) Able to read Chinese.
Exclusion criteria
Exclusion criteria: Stage 1: Participatory co-design phase (1) Diagnosed with dementia; (2) Presence of obvious communication disorders, such as severe hearing/visual impairment or severe limitations in verbal communication, making it impossible to complete assessments or follow course instructions; (3) Comorbid severe movement disorders, such as Parkinson’s disease or Huntington’s disease, making it difficult to safely participate in seated Tai Chi/stretching interventions; (4) Presence of severe cardiopulmonary disease or other unstable physical diseases, and assessed by the study physician as unsuitable for participation in this study. Stage 2: Pilot randomized controlled trial phase (1) Diagnosed with dementia; (2) Presence of obvious communication disorders, such as severe hearing/visual impairment or severe limitations in verbal communication, making it impossible to complete assessments or follow course instructions; (3) Comorbid severe movement disorders, such as Parkinson’s disease or Huntington’s disease, making it difficult to safely participate in seated Tai Chi/stretching interventions; (4) Regular participation in moderate- to high-intensity exercise or cognitive training in the past 1 year, >=3 times per week, lasting >=6 months; (5) Presence of severe cardiopulmonary disease or other unstable physical diseases, and assessed by the study physician as unsuitable for participation in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in Montreal Cognitive Assessment (MoCA) Total Score from Baseline (T0) to Post-intervention (T1); | — |
Secondary
| Measure | Time frame |
|---|---|
| Executive Function (Time to Complete Trail Making Test Part A and B);Short-term and Working Memory (Digit Span Test);Visuospatial Ability (Clock Drawing Test);Dual-task Performance (Cognitive Timed Up and Go Test);Psychological Distress (Depression, Anxiety, and Stress);Physical Mobility (Timed Up and Go Test);Exercise Self-efficacy;Health-related Quality of Life;Recruitment Rate, Attendance Rate, Dropout Rate, Protocol Adherence, Fidelity, and Adverse Event Incidence; | — |
Countries
China
Contacts
Public ContactLei Ming
Department of Neurology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University
Outcome results
None listed