Systemic lupus erythematosus
Conditions
Interventions
Observation group:None
Control group:None
Sponsors
Beijing Hospital
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Inclusion criteria for SLE patients: 1)Age >=18 years; 2)Patients diagnosed with SLE according to the 1997 ACR classification criteria for SLE, after excluding infection, malignancy, and other connective tissue diseases. 2.Inclusion criteria for healthy volunteers: Age >= 18 years;
Exclusion criteria
Exclusion criteria: 1.Exclusion criteria for SLE patients: 1)Complicated with active infections, including bacterial, viral or fungal pneumonia, tuberculosis, viral hepatitis, and central nervous system infection; 2)Severe organ failure, such as heart failure (NYHA class III or IV), liver failure, or renal failure; 3)Malignant diseases; 4)Treatment with high-dose glucocorticoids or biologic agents within the past two weeks; 5)Complicated with other autoimmune diseases; 6)Complicated with autoinflammatory diseases; 7)Pregnant or lactating women; 8)Incomplete clinical data; 9)Other conditions that are not suitable for enrollment. 2.Exclusion criteria for healthy volunteers: 1)Presence of active infections, including bacterial, viral or fungal pneumonia, tuberculosis, viral hepatitis, and central nervous system infection; 2)Severe organ failure, such as heart failure (NYHA class III or IV), liver failure, or renal failure; 3)Malignant diseases; 4)Use of high-dose glucocorticoids or biologic agents within the past two weeks; 5)Presence of other autoimmune diseases; 6)Presence of autoinflammatory diseases; 7)Pregnant or lactating women; 8)Incomplete clinical data; 9)Other conditions that render the subject ineligible for enrollment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The expression of ZBP1 in peripheral blood immune cells, including monocytes, neutrophils, and plasma cells, and its correlation with disease activity and organ complications in SLE.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum levels and oxidation status of cell-free DNA (cfDNA), IFN score, proportions of immune cell subsets, cytokine levels, and other related indicators.; | — |
Countries
China
Contacts
Public ContactYudong Liu
Beijing Hospital
Outcome results
None listed