Treatment-Resistant Schizophrenia
Conditions
Interventions
sham stimulation group:sham stimulation
active stimulation group:high-Intensity transcranial alternating current stimulation (HI-tACs)
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Han Chinese; 2. 18-65 years old; 3. Meeting the diagnostic criteria for schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5); 4. Having received at least two antipsychotic medications with different mechanisms of action at adequate doses and for sufficient durations, and currently on a stable dose of clozapine monotherapy (at least 400 mg/day or higher for a minimum of 6 months) to ensure a reasonable response to clozapine; 5.A review of the patient's medical history indicates persistent psychotic symptoms that have not been effectively controlled; 6. The patient and/or their legal guardian must provide written informed consent and agree to participate voluntarily.
Exclusion criteria
Exclusion criteria: 1. Meeting DSM-5 diagnostic criteria for other mental disorders; 2. Patients with severe physical illnesses, including cardiovascular, cerebrovascular, or pulmonary diseases, epilepsy; 3. Presence of substance and/or alcohol abuse; 4. Contraindications to electrical stimulation, such as: metallic objects or implants in the head or scalp, implanted cardiac pacemakers, skull defects or fractures, allergy to stimulation materials; 5. Women who are pregnant, in the perinatal period, or lactating; 6. Having received other brain stimulation therapies (TMS, tDCS, MECT, etc.) within the past month;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cognition;Schizophrenia positive and negative symptoms;Schizophrenia negative symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alexithymia Indicator;Dietary characteristics;Abnormal Involuntary;sleep quality;Dimensional Anhedonia;Depression symptoms;Psychological Function Indicator;Global assessment function;Brain Function Index;anxiety symptoms;Brain Function Index;Brain Function Index;Loneliness Indicator;Interpersonal reactions and expressions;Extrapyramidal side effects;Dietary characteristics; | — |
Countries
China
Contacts
Public ContactLi Shen
Tianjin Anding Hospital
Outcome results
None listed