Mild Behavioral Impairment (MBI)
Conditions
Interventions
Psychological-Sleep-Cognitive Impairment Observation Group:None
Sponsors
Shanghai Mental Health Center
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria for the multi-center cohort: 1. Multi-center cohort of sleep disorders: Elderly individuals who have been included in the Shanghai SHAPE community and clinical cohort, and the Shandong MIND rural cohort. The baseline data is complete and they meet the diagnostic criteria for any type of sleep and wake disorder according to ICD-11. The patients have signed the informed consent form. 2. Multi-center cohort of healthy controls: Elderly individuals who have been included in the Shanghai SHAPE community and clinical cohort, and the Shandong MIND rural cohort. The baseline data is complete and they do not meet the diagnostic criteria for any type of sleep and wake disorder according to ICD-11. The patients have signed the informed consent form. (Shanghai SHAPE community and clinical cohort inclusion criteria: Age >= 60 years old, residing in Shanghai, the patients or their legal guardians have signed the informed consent form, and there is no severe visual impairment. Shandong MIND rural cohort inclusion criteria: Age >= 60 years old, all registered residents of 52 villages in Yanggu County, no severe mental illness.) 3. Sub-cohort inclusion criteria: Genomic inclusion criteria: Meet the inclusion criteria for the "multi-center cohort of sleep disorders" mentioned above; agree to provide 5 milliliters of blood or 10 milliliters of cerebrospinal fluid samples for genomic sequencing and analysis; Brain network group inclusion criteria: Meet the inclusion criteria for the "genomic" mentioned above: agree to undergo brain magnetoencephalography and multimodal head magnetic resonance imaging examinations. 4. APOE4 carrying cohort inclusion criteria: Community elderly or outpatients of Shanghai Mental Health Center; Age >= 60 years old, gender not limited; at least 5 years of education; 1 or 2 APOE4 gene carriers; the patients or their legal guardians have signed the informed consent form.
Exclusion criteria
Exclusion criteria: Multicenter cohort exclusion criteria: 1. Exclude patients with severe physical diseases, those with suicidal attempts; within the past month, history of stroke, cerebrovascular accident, epilepsy, or cranial trauma; after SCID interview, exclude other Axis I mental disorders except dementia, including: schizophrenia, affective mental disorders, anxiety spectrum disorders; the researcher considers there are other situations that make them unsuitable to participate in this clinical trial. Genomic exclusion criteria: The same as the 4 items in the "multicenter cohort exclusion criteria"; have a clearly diagnosed genetic genetic disease. Brain network group exclusion criteria: The same as the 5 items in the "genomic exclusion criteria"; have magnetic metal implants in the body; have claustrophobia and cannot complete magnetic resonance examination. 2. APOE4 carrier cohort exclusion criteria Exclude patients with severe physical diseases, those with suicidal attempts; within the past month, history of stroke, cerebrovascular accident, epilepsy, or cranial trauma; after SCID interview, exclude other Axis I mental disorders except dementia, including: schizophrenia, affective mental disorders, anxiety spectrum disorders; the researcher considers there are other situations that make them unsuitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiopulmonary Coupling (CPC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Magnetoencephalography (MEG);Multimodal Magnetic Resonance Imaging (Multimodal MRI);Dense-array Electroencephalography (dEEG);Cranial PET-CT; | — |
Countries
China
Contacts
Public ContactLi Xia
Shanghai Mental Health Center
Outcome results
None listed