Chronic pulmonary diseases such as chronic obstructive pulmonary disease, bronchiectasis, and pulmonary fibrosis.
Conditions
Interventions
Chronic pulmonary disease without cor pulmonale group:None
Group of chronic pulmonary disease patients with decompensated cor pulmonale:None
Group of chronic pulmonary disease patients with compensated cor pulmonale:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Underlying chronic lung disease; 2. Diagnostic criteria for cor pulmonale: Right ventricular enlargement + Pulmonary hypertension (estimated PASP by echocardiography >= 40 mmHg). Compensated stage: TAPSE >= 17 mm (by echocardiography) with no clinical symptoms or signs of right heart failure. Decompensated stage: TAPSE < 17 mm with clinical symptoms and signs of right heart failure.
Exclusion criteria
Exclusion criteria: 1. History of acute or chronic pulmonary embolism and malignant tumors; 2. Presence of other diseases that may alter right ventricular function, such as rheumatic heart disease, cardiomyopathy, congenital heart disease, etc. 3. Presence of valvular heart disease (especially tricuspid valve disease); 4. Acute exacerbation phase (hospitalized due to infection within the past 4 weeks); 5. Contraindications to cardiac magnetic resonance (CMR) imaging or inability to cooperate with the examination (e.g., presence of pacemaker, severe claustrophobia).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| LCO/RCO; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary artery pressure;Right Ventricular Remodeling Markers (RVEDV, RVMI); | — |
Countries
China
Contacts
Public ContactYina Li
West China Hospital of Sichuan University
Outcome results
None listed