None
Conditions
Interventions
Group C:Continuous intravenous infusion of normal saline at 0.05 mL/kg/h until deep abdominal wall suture
Group E1 (Low-dose Esketamine group):Continuous intravenous infusion of Esketamine 0.125 mg/kg/h (diluted to 20 mL) at 0.05 mL/kg/h until deep abdominal wall suture
Group E2 (High-dose Esketamine group):Continuous intravenous infusion of Esketamine 0.25 mg/kg/h (diluted to 20 mL) at 0.05 mL/kg/h until deep abdominal wall suture
Sponsors
The First Affiliated Hospital of Harbin Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Aged 60 to 80 years old with no gender restriction; 2.Elderly patients undergoing elective laparoscopic renal surgery; 3.American Society of Anesthesiologists (ASA) physical status classification Grade ?-?; 4.Body Mass Index (BMI) ranging from 18 to 30 kg/m^2; 5.Normal cognitive function with a Mini-Mental State Examination (MMSE) score >= 24 points; 6.Normal communication ability and capability to cooperate with postoperative follow-up and scale evaluation; 7.Written informed consent signed by the patient or their family members.
Exclusion criteria
Exclusion criteria: 1.History of confirmed mental illness, drug or alcohol abuse; 2.Severe hepatic and renal insufficiency (liver function indicators exceeding twice the upper limit of normal, creatinine clearance rate of renal function 180/110 mmHg; 5.Combined with contraindications for esketamine use such as glaucoma and hyperthyroidism; 6.Cognitive dysfunction with MMSE score <24 points; 7.Presence of communication disorders and inability to cooperate with the completion of study-related assessments; 8.Preoperative severe cardiovascular and respiratory diseases that cannot tolerate surgery and anesthesia; 9.Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in Bispectral Index (BIS) at different time points after infusion of Esketamine or normal saline;Area under the BIS curve (AUC); | — |
Secondary
| Measure | Time frame |
|---|---|
| Spectral Edge Frequency 95 (SEF95);Heart rate (HR) and mean arterial pressure (MAP);Total intraoperative remifentanil consumption;Postoperative resting and activity numerical rating scale (NRS) pain scores; | — |
Countries
China
Contacts
Public ContactYan Wei
The First Affiliated Hospital of Harbin Medical University
Outcome results
None listed