Postoperative delirium
Conditions
Interventions
Control group:None
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age>= 65 years; 2. Undergoing coronary artery bypass grafting, aortic valve, or mitral valve surgery; 3. ASA physical status classification II-III; 4. Education level of elementary school or above; 5. Preoperative Mini-Mental State Examination (MMSE) score:>=20 for those with an elementary school education, and >=24 for those with a middle school education or above.
Exclusion criteria
Exclusion criteria: 1. Refusal to sign the informed consent form; 2. History of severe neurological or psychiatric disorders such as epilepsy, dementia, Parkinson’s disease, severe stroke, or schizophrenia, or preoperative diagnosed cognitive impairment; 3. Scalp injury at the stimulation site or skull defect; 4. Uncorrected severe visual or hearing impairment; 5. Presence of intracranial or intraorbital metallic or electronic implants (e.g., pacemakers); 6. History of drug or alcohol abuse; 7. Comorbidities of severe unstable cardiovascular disease, liver failure, or renal failure.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of postoperative delirium within 5 days after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional connectivity indices of brain networks based on resting-state and task-state fMRI;Duration and severity of delirium;Levels of peripheral blood inflammatory factors, anti-inflammatory factors, and brain-derived neurotrophic factor;Scores from the neuropsychological battery tests;Neural oscillation power spectrum and functional connectivity indices based on EEG;MRS monitors the concentration of neurotransmitters in the brain;Expression levels of extracellular trap-related markers in peripheral blood neutrophils;Anxiety (HADS-A), pain (NRS), frailty (FRAIL), and sleep quality (PSQI) scale scores; | — |
Countries
China
Contacts
Public ContactLiwei Wang
Xuzhou Central Hospital
Outcome results
None listed