Major depressive disorder
Conditions
Interventions
Control group:Healthy subjects with matched sex, age and education level were selected as the control group, and the exclusion criteria were the same as the depress
Sponsors
Tianjin Anding Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18–65 years, any sex; 2. Diagnosed with Major Depressive Disorder, current depressive episode by DSM-5 (first episode or recurrence); 3. HAMD-17 score >= 17; 4. Drug-naive or antidepressant regimen unchanged at least 4 weeks prior to consent through the study period; 5. Sufficient listening, speaking, reading, and comprehension ability to complete study assessments; 6. In the investigator’s judgment, able to understand the study purpose and procedures, comply with study requirements, and provide informed consent.
Exclusion criteria
Exclusion criteria: 1.Comorbid severe psychiatric disorders (e.g., schizophrenia, bipolar disorder) or major neurological diseases (e.g., traumatic brain injury, post-neurosurgery); 2.History or family history of epilepsy or seizure disorders; 3.Presence of cranial/cardiac/internal metal implants or electronic devices; 4.Received ECT, TMS, or other physical treatments within 30 days; 5.HAMD-17 suicide item score >= 3; 6.Participation in other interventional clinical trials; 7.Pregnant, breastfeeding, or planning pregnancy during the study; 8.Other conditions deemed unsuitable by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The 17-item Hamilton Depression Scale, HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| Facial Emotion Recognition Test;Electroencephalogram;Resting state functional MRI;Scalp EEG signals for transcranial magnetic synchronization intervention, TMS-EEG;Thinc-it;Hamilton Anxiety Scale, HAMA;Clinical efficacy global scale, CGI-S/I;16-item rapid self-rating Depression Scale, QIDS-SR16;Sness-hamilton Pleasure Scale, SHAPS;Pittsburgh Sleep Quality Index scale, PSQI;Generalized Anxiety Disorder Scale, GAD-7;Adverse Event;Positive and Negative Affect Scale (PANAS), PANAS;Toronto Alexithymia Scale, TAS-20;36-item Short Form health Survey, SF-36;World Health Organization Health-related Quality of Life Measures short form, WHOQOL-BREF; | — |
Countries
China
Contacts
Public ContactShen Li
Tianjin Anding Hospital
Outcome results
None listed