Parkinson‘disease
Conditions
Interventions
Sponsors
Union Hospital Affiliated to Fujian Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients should meet the Chinese Diagnostic Criteria for Parkinson's Disease formulated in 2016 by the Parkinson’s Disease and Movement Disorders Group of the Neurology Branch, Chinese Medical Association, with the final diagnosis jointly confirmed by at least two qualified neurologists to ensure accuracy. 2. Core diagnostic conditions include definite clinical manifestations of parkinsonism together with fulfillment of all three key requirements: (1) no absolute exclusion criteria; (2) at least two supportive diagnostic criteria; (3) absence of any warning signs (red flags).
Exclusion criteria
Exclusion criteria: 1. Inability to Cooperate with Assessments Inability to cooperate with the completion of the Unified Parkinson’s Disease Rating Scale (UPDRS) and the Mini-Mental State Examination (MMSE), resulting in failure to collect core clinical data. 2. Non-Idiopathic Parkinson’s Disease Patients with a history of recurrent stroke causing parkinsonian symptoms with stepwise deterioration, or those diagnosed with secondary parkinsonism or Parkinson-plus syndromes. Patients with non-idiopathic Parkinson’s disease are excluded to avoid confounding etiologies that may interfere with study results. 3. History of Definitive Etiological Factors Patients with a history of repetitive head trauma or a definite history of encephalitis. Such histories may induce secondary parkinsonian symptoms that are etiologically distinct from idiopathic Parkinson’s disease, and are therefore excluded. 4. Severe Comorbid Diseases Patients with concomitant severe dysfunction of vital organs (e.g., heart, liver, or kidney), severe endocrine, hematological, or autoimmune diseases, or those diagnosed with a malignant tumor. These severe comorbidities may significantly affect survival status, assessment of disease progression, and rating scale outcomes, and are therefore excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Unified Parkinson's Disease Rating Scale (UPDRS);Hoehn-yahr stage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mini-mental State Examination;Montreal Cognitive Assessment;Fatigue Severity Scale;Hamilton Depression Scale;Hamilton Anxiety Scale;Epworth Sleepiness Scale;Pittsburgh sleep quality index;REM Sleep Behavior Disorder Screening Questionnaire;Olfactory testing;Polysomnography;Functional magnetic resonance imaging;Wearable devices measure gait parameters; | — |
Countries
China
Contacts
Public ContactYe Qinyong
Union Hospital Affiliated to Fujian Medical University
Outcome results
None listed